The effect of systemic cocaine on spinal nociceptive reflex activity in the rat

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The effect of systemic cocaine on spinal nociceptive reflex activity in the rat.

In the anesthetized rat, cocaine (25 mg/kg i.p.), enhanced the frequency potentiation of nociceptively evoked polysynaptic discharges but did not affect the polysynaptic reflex discharge to single nociceptive stimuli or the habituation of this reflex to repetitive pinch stimuli. The non-nociceptive, short-latency reflex discharge was suppressed for 10-15 min after cocaine administration. The ne...

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ژورنال

عنوان ژورنال: Brain Research

سال: 1988

ISSN: 0006-8993

DOI: 10.1016/0006-8993(88)91348-0